Manganese-induced trafficking and turnover of GPP130 is mediated by sortilin
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منابع مشابه
Manganese-induced trafficking and turnover of GPP130 is mediated by sortilin
Elevated, nontoxic doses of manganese (Mn) protect against Shiga toxin-1-induced cell death via down-regulation of GPP130, a cycling Golgi membrane protein that serves as an endosome-to-Golgi trafficking receptor for the toxin. Mn binds to GPP130 in the Golgi and causes GPP130 to oligomerize/aggregate, and the complexes are diverted to lysosomes. In fact, based on experiments using the self-int...
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................................................................................................................................. 4 ACKNOWLEDGEMENTS .......................................................................................................... 6 INTRODUCTION ........................................................................................................................ 8 1.1...
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Manganese (Mn) is a trace element essential for normal human development and is required for the proper functioning of a variety of physiological processes. Chronic exposure to Mn can cause manganism, a neurodegenerative disorder resembling idiopathic Parkinson's disease (PD). Mn(II) neurotoxicity is characterized by astrocytic impairment both in the expression and activity of glutamine (Gln) t...
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ژورنال
عنوان ژورنال: Molecular Biology of the Cell
سال: 2017
ISSN: 1059-1524,1939-4586
DOI: 10.1091/mbc.e17-05-0326